Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.33 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.31 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5655318 | 0.84 | ALDH1A1 (0.47) | ALDH1A1HSD17B10KDM4EHPGDRAB9A | |
| SCHEMBL5896401 | 0.79 | PTGER4 (0.36) | ALDH1A1LMNAMAPK1KDM4EPOLB | |
| SCHEMBL7455961 | 0.75 | LMNA (0.56) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL11773969 | 0.73 | LMNA (0.63) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL3953092 | 0.72 | — | — | |
| SCHEMBL3735184 | 0.72 | DUT (0.36) | — | |
| SCHEMBL16267963 | 0.70 | ALDH1A1 (0.41) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL5476852 | 0.70 | LMNA (0.44) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL31419465 | 0.69 | ALDH1A1 (0.48) | ALDH1A1LMNATHRBTSHRMAPK1 | |
| SCHEMBL24270457 | 0.69 | LMNA (0.58) | ALDH1A1LMNATHRBTSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004136-A1 | HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME | DUFFEY MATTHEW O (US) | 2016-01-07 | — | — | WO | disclosed |