Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 3/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 3/20 | 0.34 |
| ▸ | MPL | P40238 | 5/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.32 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.31 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17412730 | 0.94 | TRPV4 (0.35) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17412762 | 0.93 | PDCD1 (0.34) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17400500 | 0.91 | MPL (0.41) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17412711 | 0.91 | MPL (0.42) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17412791 | 0.86 | ADORA3 (0.42) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17400502 | 0.86 | MPL (0.41) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL17412750 | 0.85 | ADORA3 (0.43) | PDCD1CD274MPLADORA3 | |
| SCHEMBL18724423 | 0.85 | TMEM97 (0.34) | TRPV4MPL | |
| SCHEMBL17412770 | 0.85 | ADORA3 (0.41) | PDCD1CD274TRPV4MPLADORA3 | |
| SCHEMBL18470732 | 0.85 | MPL (0.42) | PDCD1CD274MPLADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9562044-B2 | 2-acylaminothiazole derivative or salt thereof | ASTELLAS PHARMA INC. (JP) | 2017-02-07 | — | — | US | disclosed |
| US-20160002218-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | ASTELLAS PHARMA INC. (JP) | 2016-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002218-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVE OR SALT THEREOF | CHRM3, CHRM2, CHRM5 | PDCD1 4543/4885CD274 4339/4885TRPV4 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.