Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.42 |
| ▸ | ITK | Q08881 | 4/20 | 0.42 |
| ▸ | JAK3 | P52333 | 13/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | JAK1 | P23458 | 5/20 | 0.41 |
| ▸ | PLCG1 | P19174 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17413145 | 0.92 | JAK3 (0.49) | JAK3JAK2JAK1 | |
| SCHEMBL17413229 | 0.82 | JAK3 (0.61) | BTKITKJAK3JAK2JAK1 | |
| SCHEMBL17413194 | 0.81 | JAK3 (0.43) | JAK3JAK2JAK1 | |
| SCHEMBL17412969 | 0.76 | BTK (0.59) | BTKITKJAK3JAK2JAK1 | |
| SCHEMBL17412995 | 0.76 | BTK (0.54) | BTKITKJAK3PLCG1 | |
| SCHEMBL17413148 | 0.76 | JAK3 (0.58) | JAK3JAK2JAK1 | |
| SCHEMBL17412970 | 0.74 | JAK3 (0.70) | JAK3JAK2JAK1 | |
| SCHEMBL17412953 | 0.73 | BTK (0.51) | BTKITKJAK3PLCG1 | |
| SCHEMBL17412986 | 0.72 | PLCG1 (0.59) | BTKITKJAK3PLCG1 | |
| SCHEMBL17413172 | 0.72 | JAK3 (0.59) | ITKJAK3JAK2JAK1PLCG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016000615-A1 | HETEROARYL COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2016-01-07 | — | — | WO | disclosed |