Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | GUSB | P08236 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2572783 | 0.85 | TSHR (0.66) | TSHRGUSBGAAHSD17B10USP2 | |
| SCHEMBL17413884 | 0.84 | TSHR (0.71) | TSHRGUSBGAAHSD17B10USP2 | |
| SCHEMBL17413873 | 0.82 | TSHR (0.68) | TSHRGUSBHSD17B10USP2ALDH1A1 | |
| SCHEMBL19752621 | 0.80 | TSHR (0.76) | TSHRGUSBGAAHSD17B10ALDH1A1 | |
| SCHEMBL19752620 | 0.80 | TSHR (0.76) | TSHRGUSBGAAHSD17B10ALDH1A1 | |
| SCHEMBL2569551 | 0.76 | GRK2 (0.81) | — | |
| SCHEMBL10113416 | 0.76 | ADORA2B (0.66) | TSHRGUSBGAAHSD17B10CA12 | |
| SCHEMBL17413871 | 0.75 | TSHR (1.00) | TSHRGAAUSP2ALDH1A1KDM4E | |
| SCHEMBL17413861 | 0.74 | TSHR (0.67) | TSHRGUSBUSP2ALDH1A1KDM4E | |
| SCHEMBL2567107 | 0.74 | GRK2 (0.77) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016004028-A1 | 2-OXOPYRIMIDINE-5-CARBOXYLATE DERIVATIVES FOR TREATING THYROID DISEASES | LATIF RAUF (US) | 2016-01-07 | — | — | WO | disclosed |