Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.47 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.42 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.42 |
| ▸ | ITGAL | P20701 | 1/20 | 0.42 |
| ▸ | PTGER3 | P43115 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CRHBP | P24387 | 2/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.35 |
| ▸ | WNT3A | P56704 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13255085 | 0.82 | ABCG2 (0.52) | MAP3K14PTGER3SMN1; SMN2NPC1RAB9A | |
| SCHEMBL19928557 | 0.81 | DRD1 (0.36) | MAP3K14ITGB2ICAM1ITGALPTGER3 | |
| SCHEMBL436487 | 0.81 | MAP3K14 (0.46) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL9913796 | 0.78 | DRD1 (0.36) | MAP3K14ITGB2ICAM1ITGALPTGER3 | |
| SCHEMBL436160 | 0.77 | MAP3K14 (0.46) | MAP3K14ITGB2ICAM1ITGALACHE | |
| SCHEMBL769591 | 0.76 | MAP3K14 (0.42) | MAP3K14ITGB2ICAM1ITGALPTGER3 | |
| SCHEMBL13516866 | 0.74 | ITGB2 (0.42) | MAP3K14ITGB2ICAM1ITGALLMNA | |
| SCHEMBL27915696 | 0.74 | HTR7 (0.53) | SMN1; SMN2RAB9ACTNNB1WNT3AMAPT | |
| SCHEMBL13191525 | 0.74 | MAP3K14 (0.40) | MAP3K14ITGB2ICAM1ITGALACHE | |
| SCHEMBL9351 | 0.73 | ITGB2 (0.77) | ITGB2ICAM1ITGALLMNACRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9828340-B2 | Asymmetric synthesis of a substituted pyrrolidine-2-carboxamide | HOFFMANN-LA ROCHE INC. (US) | 2017-11-28 | — | — | US | disclosed |
| EP-2958893-B1 | ASYMMETRIC SYNTHESIS OF A SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDE | HOFFMANN LA ROCHE (CH) | 2017-05-03 | — | — | EP | disclosed |
| US-20160002158-A1 | ASYMMETRIC SYNTHESIS OF A SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDE | HOFFMANN-LA ROCHE AG (US) | 2016-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160002158-A1 | ASYMMETRIC SYNTHESIS OF A SUBSTITUTED PYRROLIDINE-2-CARBOXAMIDE | ALDH18A1, PAH, DDC | MAP3K14 3260/4885ITGB2 4586/4885ICAM1 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.