Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 9/20 | 0.35 |
| ▸ | RAB9A | P51151 | 8/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905363 | 0.85 | PLK1 (0.40) | PLK1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL668148 | 0.81 | ABCB1 (0.44) | PLK1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL18091855 | 0.81 | PLK1 (0.41) | PLK1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL9102042 | 0.80 | PLK1 (0.38) | PLK1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL5705240 | 0.77 | NPC1 (0.39) | NPC1RAB9ASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL668714 | 0.77 | ABCB1 (0.55) | PLK1 | |
| SCHEMBL9103547 | 0.74 | ABCB1 (0.40) | NPC1RAB9AMAPTMEN1KMT2A | |
| SCHEMBL668149 | 0.74 | PLK1 (0.38) | PLK1NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL668088 | 0.74 | ABCB1 (0.53) | PLK1 | |
| SCHEMBL667456 | 0.73 | PLK1 (0.39) | PLK1NPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2463269-B1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-09-28 | — | — | EP | disclosed |
| EP-2460786-B1 | Bioavailable diacylhydrazine ligands for modulating the expression of exogenous genes via an ecdysone receptor complex | INTREXON CORP (US) | 2016-01-13 | — | — | EP | disclosed |