Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | RAB9A | P51151 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9905363 | 0.86 | PLK1 (0.40) | NPC1RAB9AMAPTALDH1A1LMNA | |
| SCHEMBL18091876 | 0.84 | CTNNB1 (0.46) | NPC1RAB9AMAPTHTTLMNA | |
| SCHEMBL7130710 | 0.84 | NPC1 (0.38) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL14937148 | 0.83 | NPC1 (0.32) | NPC1RAB9AHTTCYP3A4CYP2C9 | |
| SCHEMBL16036692 | 0.83 | ABCB1 (0.32) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL9903289 | 0.83 | NPC1 (0.35) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL16239577 | 0.83 | ABCB1 (0.33) | RAB9AHTTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL14764988 | 0.83 | ABCB1 (0.34) | NPC1RAB9AMAPTALDH1A1HTT | |
| SCHEMBL6123388 | 0.82 | NPC1 (0.35) | NPC1RAB9AMAPTSMN1; SMN2 | |
| SCHEMBL19946456 | 0.81 | HSD17B10 (0.36) | NPC1RAB9AMAPTALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1076569-A1 | FORMULATIONS USEFUL FOR MODULATING EXPRESSION OF EXOGENOUS GENES IN MAMMALIAN SYSTEMS, AND PRODUCTS RELATED THERETO | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 2001-02-21 | — | — | EP | claimed |
| WO-1999058155-A1 | FORMULATIONS USEFUL FOR MODULATING EXPRESSION OF EXOGENOUS GENES IN MAMMALIAN SYSTEMS, AND PRODUCTS RELATED THERETO | THE SALK INSTITUTE FOR BIOLOGICAL STUDIES (US) | 1999-11-18 | — | — | WO | claimed |
| EP-1266015-B1 | ECDYSONE RECEPTOR-BASED INDUCIBLE GENE EXPRESSION SYSTEM | RHEOGENE HOLDINGS INC (US) | 2006-08-30 | — | — | EP | disclosed |