Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.56 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.56 |
| ▸ | F12 | P00748 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 1/20 | 0.56 |
| ▸ | NOS3 | P29474 | 1/20 | 0.56 |
| ▸ | NOS1 | P29475 | 1/20 | 0.56 |
| ▸ | NOS2 | P35228 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CFTR | P13569 | 1/20 | 0.44 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30531504 | 1.00 | PLAU (0.56) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL27953035 | 0.84 | RAB9A (0.47) | PLAUCYP2A6F12NCF1NOS3 | |
| Hydrochlorthiazide SCHEMBL2541220 | 0.82 | PLAU (0.41) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL199273 | 0.75 | PLAU (0.60) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL29923403 | 0.75 | PLAU (0.60) | PLAUCYP2A6F12NCF1NOS3 | |
| Bromide SCHEMBL23499951 | 0.74 | PLAU (0.54) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL30493902 | 0.74 | MAPT (0.49) | MAPTKDM4E | |
| SCHEMBL30522769 | 0.73 | PLAU (0.58) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL24663121 | 0.73 | CYP2A6 (0.58) | PLAUCYP2A6F12NCF1NOS3 | |
| SCHEMBL4797349 | 0.73 | PLAU (0.58) | PLAUCYP2A6F12NCF1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117865932-B | Preparation method of benzothiophene sulfone compound with medicinal and fluorescent activity | BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | claimed |
| CN-115747843-B | Electrochemical preparation method for synthesizing fluoroisoquinoline-1, 3-diketone compound by trifluoromethyl/cyclization | 兰州石化职业技术大学 | 2025-01-24 | — | — | CN | claimed |
| CN-117865932-A | Preparation method of benzothiophene sulfone compound with medicinal and fluorescent activity | 北京化工大学 | 2024-04-12 | — | — | CN | claimed |
| CN-115747843-A | Electrochemical preparation method for synthesizing fluoroisoquinoline-1,3-diketone compound through trifluoromethylation/cyclization | 兰州石化职业技术大学 | 2023-03-07 | — | — | CN | claimed |
| CN-102812014-B | The purposes of novel 9 oxime derivate and the allosteric modulators as metabotropic glutamate receptor thereof | DOMAIN THERAPEUTICS (FR) | 2016-01-20 | — | — | CN | claimed |
| CN-103483337-B | Fluorinated isoquinoline [a] pyrrole compounds and preparation method thereof | SHANGHAI INST ORGANIC CHEM | 2015-02-18 | — | — | CN | claimed |
| CN-103483255-B | Fluorinated isoquinoline compounds and preparation method thereof | SHANGHAI INST ORGANIC CHEM | 2015-02-18 | — | — | CN | claimed |
| CN-103483255-A | Fluorinated isoquinoline compounds and preparation method thereof | SHANGHAI INST ORGANIC CHEM | 2014-01-01 | — | — | CN | claimed |
| CN-103483337-A | Fluorinated isoquinoline [a] pyrrole compounds and preparation method thereof | SHANGHAI INST ORGANIC CHEM | 2014-01-01 | — | — | CN | claimed |
| EP-0825987-B1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | AVENTIS RES & TECH GMBH & CO (DE) | 1999-12-01 | — | — | EP | claimed |
| US-5911913-A | 1-fluoroisoquinoline derivatives and the use thereof in liquid crystalline mixtures | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-06-15 | — | — | US | claimed |
| EP-0916714-A1 | Chiral smectic liquid crystal mixture containing fluoroisoquinolines | Aventis Research & Technologies GmbH & Co. KG (DE) | 1999-05-19 | — | — | EP | claimed |
| CN-117865932-B | Preparation method of benzothiophene sulfone compound with medicinal and fluorescent activity | BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY (CN) | 2026-05-26 | — | — | CN | disclosed |
| US-20250145574-A1 | FLUOROISOQUINOLINE COMPOUND AND PRODUCTION METHOD THEREOF | CARNA BIOSCIENCES, INC. (JP) | 2025-05-08 | — | — | US | disclosed |
| CN-115747843-B | Electrochemical preparation method for synthesizing fluoroisoquinoline-1, 3-diketone compound by trifluoromethyl/cyclization | 兰州石化职业技术大学 | 2025-01-24 | — | — | CN | disclosed |
| CN-115747843-B | Electrochemical preparation method for synthesizing fluoroisoquinoline-1, 3-diketone compound by trifluoromethyl/cyclization | 兰州石化职业技术大学 | 2025-01-24 | — | — | CN | disclosed |
| EP-0916714-A1 | Chiral smectic liquid crystal mixture containing fluoroisoquinolines | Aventis Research & Technologies GmbH & Co. KG (DE) | 1999-05-19 | — | — | EP | disclosed |
| EP-0916714-A1 | Chiral smectic liquid crystal mixture containing fluoroisoquinolines | Aventis Research & Technologies GmbH & Co. KG (DE) | 1999-05-19 | — | — | EP | disclosed |
| EP-0825987-A1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-03-04 | — | — | EP | disclosed |
| WO-1996035674-A1 | 1-FLUORISOQUINOLINE DERIVATIVES AND THE USE THEREOF IN LIQUID CRYSTALLINE MIXTURES | HOECHST AKTIENGESELLSCHAFT (DE) | 1996-11-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250145574-A1 | FLUOROISOQUINOLINE COMPOUND AND PRODUCTION METHOD THEREOF | BTK, SYK, ABL1 | PLAU 4498/4885CYP2A6 2028/4885F12 760/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.