Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 3/20 | 0.42 |
| ▸ | PPARA | Q07869 | 3/20 | 0.42 |
| ▸ | KIF11 | P52732 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28572268 | 0.81 | TRPA1 (0.44) | KMT2APPARGPPARACA1CA2 | |
| SCHEMBL11039747 | 0.80 | CA2 (0.42) | KMT2APPARGPPARACA1CA2 | |
| SCHEMBL22441312 | 0.79 | TAAR1 (0.47) | KMT2ANPC1RAB9A | |
| SCHEMBL21378558 | 0.79 | TAAR1 (0.47) | KMT2ANPC1RAB9A | |
| SCHEMBL3589541 | 0.79 | TAAR1 (0.47) | KMT2ANPC1RAB9A | |
| SCHEMBL11848566 | 0.78 | SLC6A2 (0.48) | KMT2APPARGPPARA | |
| SCHEMBL6141386 | 0.75 | PPARA (0.43) | KMT2APPARGPPARAALDH1A1NPC1 | |
| SCHEMBL13169222 | 0.75 | KIF11 (0.41) | KMT2AKIF11CA1CA2 | |
| SCHEMBL18740032 | 0.75 | KIF11 (0.41) | KMT2AKIF11CA1CA2 | |
| SCHEMBL3058615 | 0.75 | KIF11 (0.41) | KMT2AKIF11CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387570-A1 | FLUOROISOQUINOLINE SUBSTITUTED THIAZOLE COMPOUNDS AND METHODS OF USE | Amgen, Inc (US) | 2011-11-23 | — | — | EP | disclosed |