Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.40 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.40 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17420313 | 0.87 | SLC16A3 (0.52) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL17420285 | 0.80 | TERT (0.60) | PIM2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17420335 | 0.80 | TERT (0.56) | PIM2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17420298 | 0.79 | PIM2 (0.53) | PIM2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL17420314 | 0.77 | KDM4E (0.52) | PIM2ALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL9837631 | 0.77 | HTR3E (0.49) | ALDH1A1KDM4ETSHRCYP3A4USP2 | |
| SCHEMBL17420283 | 0.74 | PIM2 (0.48) | PIM2ALDH1A1KDM4EPOLBTDP1 | |
| SCHEMBL24532544 | 0.73 | MEN1 (0.47) | ALDH1A1MEN1KMT2AKDM4EPOLB | |
| SCHEMBL17420281 | 0.72 | PIM2 (0.51) | PIM2ALDH1A1KDM4ETSHRCYP3A4 | |
| SCHEMBL17420317 | 0.72 | HRH3 (0.43) | PIM2TSHRUSP2MGAMHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9890162-B2 | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890162-B2 | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2018-02-13 | — | — | US | disclosed |
| US-9890162-B2 | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors | INCYTE CORPORATION (US) | 2018-02-13 | — | — | US | disclosed |
| US-20170253587-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-20170253587-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-20170253587-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2017-09-07 | — | — | US | disclosed |
| US-9580418-B2 | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580418-B2 | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-9580418-B2 | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors | INCYTE CORPORATION (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160009714-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2016-01-14 | — | — | US | disclosed |
| US-20160009714-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2016-01-14 | — | — | US | disclosed |
| US-20160009714-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | INCYTE CORPORATION | 2016-01-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160009714-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | PIM2 2/4885ALDH1A1 2531/4885MEN1 4226/4885 |
| US-20170253587-A1 | BICYCLIC AROMATIC CARBOXAMIDE COMPOUNDS USEFUL AS PIM KINASE INHIBITORS | PIM1, PIM2, PIM3 | PIM2 2/4885ALDH1A1 2531/4885MEN1 4226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.