SCHEMBL17420840

SCHEMBL17420840

COC(=O)CCN1CCOC(=O)OCC1

nearest known ligand 0.50

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.50
KDM4E B2RXH2 1/20 0.42
ALDH1A1 P00352 1/20 0.42
GLA P06280 2/20 0.41
TSHR P16473 1/20 0.39
KAT2B Q92831 2/20 0.39
RAB9A P51151 1/20 0.38
CACNA1C Q13936 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
POLB P06746 1/20 0.38
MAPK1 P28482 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
MEN1 O00255 1/20 0.38
KMT2A Q03164 1/20 0.38
LMNA P02545 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17420838 0.83 SMN1; SMN2 (0.41) SMN1; SMN2KDM4EALDH1A1GLARAB9A
SCHEMBL66238 0.82 GLA (0.58) SMN1; SMN2ALDH1A1GLARAB9ATDP1
SCHEMBL17430957 0.81 PAOX (0.43) SMN1; SMN2ALDH1A1GLARAB9AL3MBTL1
Hydrochloric Acid SCHEMBL17895217 0.81 GLA (0.61) SMN1; SMN2ALDH1A1GLARAB9ATDP1
SCHEMBL4489670 0.80 SMN1; SMN2 (0.65) SMN1; SMN2KDM4EALDH1A1GLATSHR
SCHEMBL1174392 0.80
SCHEMBL6429098 0.77 SMN1; SMN2 (0.54) SMN1; SMN2KDM4EALDH1A1TSHRKAT2B
SCHEMBL20329218 0.77 KDM4E (0.41) SMN1; SMN2KDM4EALDH1A1GLATSHR
SCHEMBL65886 0.76 SMN1; SMN2 (0.61) SMN1; SMN2KDM4EALDH1A1GLATSHR
SCHEMBL1725970 0.76 SMN1; SMN2 (0.61) SMN1; SMN2KDM4EALDH1A1TSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9951179-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-9951179-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-9951179-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2018-04-24 US disclosed
US-20170158811-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-06-08 US disclosed
US-20170158811-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-06-08 US disclosed
US-20170158811-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM INTERNATIONAL BUSINESS MACHINES CORPORATION 2017-06-08 US disclosed
US-9624191-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-04-18 US disclosed
US-9624191-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-04-18 US disclosed
US-9624191-B2 Cyclic carbonate monomers and ring opened polycarbonates therefrom INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2017-04-18 US disclosed
US-20160009860-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-01-14 US disclosed
US-20160009860-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-01-14 US disclosed
US-20160009860-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) 2016-01-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009860-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM ACMSD, CARM1, PBRM1 SMN1; SMN2 4168/4885KDM4E 1819/4885ALDH1A1 4808/4885
US-20170158811-A1 CYCLIC CARBONATE MONOMERS AND RING OPENED POLYCARBONATES THEREFROM ACMSD, CARM1, PBRM1 SMN1; SMN2 4168/4885KDM4E 1819/4885ALDH1A1 4808/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.