Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 3/20 | 0.49 |
| ▸ | ANPEP | P15144 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13403397 | 0.71 | MMP2 (0.60) | MMP2ANPEPBRD4FKBP1A | |
| SCHEMBL2691165 | 0.71 | MMP2 (0.60) | MMP2ANPEPBRD4FKBP1A | |
| SCHEMBL17973099 | 0.71 | MMP2 (0.60) | MMP2ANPEPBRD4FKBP1A | |
| SCHEMBL29192026 | 0.70 | — | — | |
| SCHEMBL14770252 | 0.69 | MMP2 (0.58) | MMP2ANPEPBRD4FKBP1A | |
| SCHEMBL8404080 | 0.68 | MMP2 (0.57) | MMP2ANPEPBRD4 | |
| SCHEMBL8404107 | 0.68 | MMP2 (0.57) | MMP2ANPEPBRD4 | |
| SCHEMBL8404149 | 0.68 | MMP2 (0.57) | MMP2ANPEPBRD4 | |
| SCHEMBL15083833 | 0.68 | MMP2 (0.57) | MMP2ANPEPBRD4 | |
| SCHEMBL3973783 | 0.68 | MMP2 (0.57) | MMP2ANPEPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3166939-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | Genentech, Inc. (US) | 2017-05-17 | — | — | EP | disclosed |
| WO-2016007534-A1 | THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2016-01-14 | — | — | WO | disclosed |