Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 5/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | LTA4H | P09960 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 3/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1681065 | 0.84 | CYP19A1 (0.50) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL11473119 | 0.82 | CYP19A1 (0.49) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL2194408 | 0.82 | CYP19A1 (0.66) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL31528097 | 0.81 | CYP19A1 (1.00) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL2023479 | 0.81 | CYP19A1 (1.00) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL16114401 | 0.79 | LMNA (0.75) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL676142 | 0.79 | LMNA (0.82) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL30535283 | 0.79 | LMNA (0.82) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL13889297 | 0.78 | CYP19A1 (0.56) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 | |
| SCHEMBL522790 | 0.77 | CYP19A1 (1.00) | CYP19A1ALDH1A1SMN1; SMN2CYP11B1CYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |
| WO-2016007837-A1 | CARBONYL LINKED BICYCLIC HETEROARYL ANTIBIOTIC TOLERANCE INHIBITORS | SPERO THERAPEUTICS, INC. (US) | 2016-01-14 | — | — | WO | disclosed |