Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS2R14 | Q9NYV8 | 8/20 | 0.61 |
| ▸ | FABP4 | P15090 | 2/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 6/20 | 0.54 |
| ▸ | AKR1C2 | P52895 | 5/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | AKR1B10 | O60218 | 3/20 | 0.54 |
| ▸ | AKR1C1 | Q04828 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.54 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.54 |
| ▸ | DHFR | P00374 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14580629 | 0.86 | TAS2R14 (0.70) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL2625434 | 0.82 | TAS2R14 (0.65) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL1649780 | 0.82 | TTR (0.62) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL11611911 | 0.79 | TTR (0.67) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL18109767 | 0.79 | FABP4 (0.85) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL4249837 | 0.78 | FABP4 (0.71) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL5680799 | 0.78 | FABP4 (0.71) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL28133218 | 0.77 | FABP4 (0.75) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL10144302 | 0.77 | AKR1C3 (0.68) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 | |
| SCHEMBL29391834 | 0.77 | AKR1C3 (0.68) | TAS2R14FABP4AKR1C3AKR1C2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233107-B2 | Compositions and methods for the treatment of progressive multifocal leukoencephalopathy (PML) | BIOGEN MA INC. (US) | 2016-01-12 | — | — | US | disclosed |