Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 3/20 | 0.44 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | FURIN | P09958 | 7/20 | 0.36 |
| ▸ | GNPAT | O15228 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.34 |
| ▸ | NPY1R | P25929 | 2/20 | 0.34 |
| ▸ | NPY4R | P50391 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17424361 | 0.89 | SIRT5 (0.45) | SIRT5SIRT6SIRT1KISS1RSIRT2 | |
| SCHEMBL17424367 | 0.89 | SIRT5 (0.45) | SIRT5SIRT6SIRT1KISS1RSIRT2 | |
| SCHEMBL17424369 | 0.89 | SIRT5 (0.44) | SIRT5SIRT6SIRT1KISS1RSIRT2 | |
| SCHEMBL17424366 | 0.88 | KISS1R (0.47) | SIRT5SIRT6SIRT1KISS1RNPY5R | |
| SCHEMBL17424390 | 0.88 | SIRT5 (0.44) | SIRT5SIRT6SIRT1KISS1RSIRT2 | |
| SCHEMBL12035276 | 0.88 | SIRT5 (0.44) | SIRT5SIRT6SIRT1KISS1RNPY5R | |
| SCHEMBL17424365 | 0.86 | SIRT5 (0.44) | SIRT5SIRT6SIRT1KISS1RSIRT2 | |
| SCHEMBL17424379 | 0.85 | SIRT5 (0.42) | SIRT5SIRT6SIRT1SIRT2FURIN | |
| SCHEMBL17424409 | 0.83 | NPY4R (0.40) | SIRT5SIRT2FURINNPY5RNPY1R | |
| SCHEMBL17424364 | 0.82 | SIRT5 (0.40) | SIRT5SIRT6SIRT1KISS1RSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233086-B2 | Inhibition of WDR5 interaction with its binding partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-12 | — | — | US | disclosed |