Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 6/20 | 0.36 |
| ▸ | NPY1R | P25929 | 5/20 | 0.36 |
| ▸ | NPY4R | P50391 | 5/20 | 0.36 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.36 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.36 |
| ▸ | QRFPR | Q96P65 | 1/20 | 0.35 |
| ▸ | FURIN | P09958 | 5/20 | 0.35 |
| ▸ | NPY2R | P49146 | 3/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | NMT2 | O60551 | 1/20 | 0.34 |
| ▸ | NMT1 | P30419 | 1/20 | 0.34 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.34 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12035268 | 0.88 | NPY4R (0.46) | SIRT5F2NPY5RNPY1RNPY4R | |
| SCHEMBL17424369 | 0.85 | SIRT5 (0.44) | SIRT5NPY5RNPY1RNPY4RSIRT6 | |
| SCHEMBL17424367 | 0.83 | SIRT5 (0.45) | SIRT5SIRT6SIRT1QRFPRFURIN | |
| SCHEMBL17424361 | 0.83 | SIRT5 (0.45) | SIRT5SIRT6SIRT1FURINSIRT2 | |
| SCHEMBL17424366 | 0.82 | KISS1R (0.47) | SIRT5NPY5RNPY1RNPY4RSIRT6 | |
| SCHEMBL17424365 | 0.82 | SIRT5 (0.44) | SIRT5SIRT6SIRT1FURINSIRT2 | |
| SCHEMBL17424360 | 0.82 | SIRT5 (0.44) | SIRT5NPY5RNPY1RNPY4RSIRT6 | |
| SCHEMBL17424409 | 0.81 | NPY4R (0.40) | SIRT5NPY5RNPY1RNPY4RFURIN | |
| SCHEMBL17424379 | 0.81 | SIRT5 (0.42) | SIRT5SIRT6SIRT1FURINSIRT2 | |
| SCHEMBL17424441 | 0.80 | NPY5R (0.42) | NPY5RNPY1RNPY4RFURINNPY2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233086-B2 | Inhibition of WDR5 interaction with its binding partners | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2016-01-12 | — | — | US | disclosed |