Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | VIM | P08670 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | MC3R | P41968 | 1/20 | 0.40 |
| ▸ | MC1R | Q01726 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BMP1 | P13497 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17424480 | 0.92 | CREBBP (0.40) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL13671131 | 0.83 | CREBBP (0.51) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL12754797 | 0.82 | CREBBP (0.50) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL17424484 | 0.81 | CREBBP (0.49) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL21565404 | 0.80 | CREBBP (0.50) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL20906815 | 0.80 | CREBBP (0.55) | CREBBPVIMMC4RMC3RALDH1A1 | |
| SCHEMBL25696093 | 0.77 | ALDH1A1 (0.46) | CREBBPGAAVIMMC4RMC3R | |
| SCHEMBL20906872 | 0.76 | CREBBP (0.42) | CREBBPGAAALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL20906849 | 0.76 | CREBBP (0.51) | CREBBPVIMMC4RMC3RALDH1A1 | |
| SCHEMBL17366443 | 0.73 | CREBBP (0.43) | CREBBPVIMMC4RMC3RALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9233162-B2 | High affinity VEGF-receptor antagonists | THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2016-01-12 | — | — | US | disclosed |