Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACKR3 | P25106 | 5/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.48 |
| ▸ | KMT5A | Q9NQR1 | 1/20 | 0.42 |
| ▸ | FAAH | O00519 | 3/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1743929 | 0.87 | TLR8 (0.50) | ACKR3SIGMAR1TLR8KMT5AADORA3 | |
| SCHEMBL103380 | 0.87 | ACKR3 (0.50) | ACKR3SIGMAR1TLR8ADORA3HTR2A | |
| SCHEMBL1742612 | 0.84 | ACKR3 (0.49) | ACKR3SIGMAR1TLR8KMT5AADORA3 | |
| SCHEMBL1744477 | 0.83 | SIGMAR1 (0.50) | ACKR3SIGMAR1TLR8ADORA3HTR2A | |
| SCHEMBL7971782 | 0.82 | SIGMAR1 (0.69) | ACKR3SIGMAR1FAAHADORA3HTR2A | |
| SCHEMBL1438607 | 0.81 | GPR4 (0.50) | ACKR3 | |
| SCHEMBL31752794 | 0.81 | SIGMAR1 (0.56) | ACKR3SIGMAR1TLR8FAAHADORA3 | |
| SCHEMBL12161250 | 0.80 | SIGMAR1 (0.47) | ACKR3SIGMAR1TLR8KMT5AADORA3 | |
| SCHEMBL27197786 | 0.80 | ACKR3 (0.47) | ACKR3CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL1742600 | 0.79 | SIGMAR1 (0.49) | ACKR3SIGMAR1TLR8KMT5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1981889-B1 | CYTOTOXIC AGENTS COMPRISING NEW TOMAYMYCIN DERIVATIVES AND THEIR THERAPEUTIC USE | SANOFI SA (FR) | 2014-01-15 | — | — | EP | disclosed |
| EP-2386559-A1 | Cytotoxiv agents comprising new tomaymycin derivatives and their therapeutic use | SANOFI (FR) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254808-A1 | REFLECTIVE TOUCH DISPLAY PANEL AND MANUFACTURING METHOD THEREOF | AU OPTRONICS CORPORATION (TW) | 2011-10-20 | — | — | US | disclosed |
| EP-2371827-A1 | Cytotoxic agents comprising new tomaymycin derivatives and their therapeutic use | SANOFI (FR) | 2011-10-05 | — | — | EP | disclosed |