SCHEMBL17427475

SCHEMBL17427475

Cn1ncnc1NC(=O)c1cn(C)c(=O)n(-c2ccccc2)c1=O

nearest known ligand 0.41

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
TYRO3 Q06418 6/20 0.41
MET P08581 7/20 0.39
AXL P30530 3/20 0.39
MERTK Q12866 5/20 0.38
MEN1 O00255 1/20 0.36
RAB9A P51151 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17427482 0.81 TYRO3 (0.38) TYRO3METMEN1RAB9AKMT2A
SCHEMBL17427477 0.81 MET (0.38) TYRO3METAXLMEN1RAB9A
SCHEMBL16401887 0.74 GSK3A (0.47) MEN1KMT2A
SCHEMBL17409840 0.68 KMT2A (0.48) RAB9AKMT2A
SCHEMBL24400184 0.67 NTRK1 (0.48) RAB9A
SCHEMBL17427479 0.66 POLB (0.47) METAXLRAB9AKMT2A
SCHEMBL17427476 0.66 MERTK (0.38) TYRO3METAXLMERTKRAB9A
SCHEMBL17427480 0.66 NPC1 (0.46) METAXLMERTKRAB9AKMT2A
SCHEMBL17427481 0.65 HPGD (0.53) METAXLMERTKRAB9A
SCHEMBL31091404 0.65 NOTUM (0.51) MEN1RAB9AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed
US-20160009693-A1 HERBICIDAL COMPOUNDS SYNGENTA LIMITED (GB) 2016-01-14 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160009693-A1 HERBICIDAL COMPOUNDS DDT, HAX1, CYP4X1 TYRO3 4178/4885MET 3504/4885AXL 3850/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.