Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.57 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.52 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.52 |
| ▸ | SOAT1 | P35610 | 2/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.47 |
| ▸ | METAP2 | P50579 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NCF1 | P14598 | 1/20 | 0.45 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.45 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17035908 | 0.88 | ADRB1 (0.60) | ADRB1ADRB2KDM4EABL1LMNA | |
| SCHEMBL30101389 | 0.88 | ADRB1 (0.60) | ADRB1ADRB2KDM4EABL1LMNA | |
| SCHEMBL231823 | 0.88 | ADRB1 (0.60) | ADRB1ADRB2KDM4EABL1LMNA | |
| Hydrochloric Acid SCHEMBL9530917 | 0.86 | ADRB1 (0.59) | ADRB1ADRB2KDM4EABL1LMNA | |
| Hydrochloric Acid SCHEMBL9394896 | 0.86 | ADRB1 (0.59) | ADRB1ADRB2KDM4EABL1LMNA | |
| SCHEMBL5623553 | 0.85 | KDM4E (0.59) | KCNH2DGAT1SOAT1MGLLKDM4E | |
| SCHEMBL6785729 | 0.84 | ADRB1 (0.49) | ADRB1KCNH2PIM1PIM3PIM2 | |
| SCHEMBL12911528 | 0.83 | GPR119 (0.58) | GPR119KCNH2CACNA1CASIC3IKBKE | |
| SCHEMBL2155294 | 0.82 | ADRB1 (0.55) | ADRB1KDM4EABL1LMNA | |
| SCHEMBL30567235 | 0.82 | ADRB1 (0.55) | ADRB1KDM4EABL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8846677-B2 | Medicaments | HIGH POINT PHARMACEUTICALS, LLC (US) | 2014-09-30 | — | — | US | disclosed |
| US-8501739-B2 | Medicaments | HIGH POINT PHARMACEUTICALS, LLC (US) | 2013-08-06 | — | — | US | disclosed |
| US-20120232078-A1 | Novel Medicaments | HIGH POINT PHARMACEUTICALS, LLC (US) | 2012-09-13 | — | — | US | disclosed |
| EP-2386554-A1 | Compounds active at the histamine H3 receptor | High Point Pharmaceuticals, LLC (US) | 2011-11-16 | — | — | EP | disclosed |
| EP-2233470-A1 | Histamine H3 receptor antagonists | High Point Pharmaceuticals, LLC (US) | 2010-09-29 | — | — | EP | disclosed |
| US-20090312309-A1 | Novel Medicaments | HIGH POINT PHARMACEUTICALS, LLC (US) | 2009-12-17 | — | — | US | disclosed |
| EP-1902028-A2 | HISTAMINE H3 RECEPTOR ANTAGONISTS | Novo Nordisk A/S (DK) | 2008-03-26 | — | — | EP | disclosed |
| WO-2007003604-A2 | HISTS1MINE H3 RECEPTOR ANTAGONISTS | NOVO NORDISK A/S (DK) | 2007-01-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120232078-A1 | Novel Medicaments | HRH3, HRH4, HRH1 | GPR119 198/4885ADRB1 336/4885KCNH2 2830/4885 |
| US-20090312309-A1 | Novel Medicaments | HRH3, HRH4, HRH1 | GPR119 198/4885ADRB1 336/4885KCNH2 2830/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.