Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 7/20 | 0.45 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 9/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | CYBB | P04839 | 3/20 | 0.41 |
| ▸ | NOX5 | Q96PH1 | 1/20 | 0.41 |
| ▸ | PDCD1 | Q15116 | 6/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17434079 | 0.82 | TSHR (0.46) | CD274PDCD1LG2PDE10ANCF1BACE1 | |
| SCHEMBL17434040 | 0.75 | TSHR (0.54) | CD274PDCD1LG2PDE10ABACE1PDCD1 | |
| SCHEMBL17434039 | 0.75 | TSHR (0.54) | CD274PDCD1LG2PDE10ABACE1PDCD1 | |
| SCHEMBL17433846 | 0.73 | PDE10A (0.47) | PDE10ANCF1BACE1 | |
| SCHEMBL17433997 | 0.72 | BACE1 (0.51) | NCF1BACE1CYBBNOX5 | |
| SCHEMBL31361282 | 0.69 | LTA4H (0.38) | CD274PDCD1LG2PDCD1MCHR1 | |
| SCHEMBL610614 | 0.68 | LTA4H (0.43) | CD274PDCD1MCHR1 | |
| SCHEMBL20238359 | 0.68 | SCN1A (0.46) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL29668762 | 0.68 | SCN1A (0.46) | CD274PDCD1LG2PDCD1 | |
| SCHEMBL17433987 | 0.67 | NCF1 (0.51) | NCF1BACE1CYBBNOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-9464076-B2 | Benzothiophene derivative | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-10-11 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-28 | — | — | US | disclosed |
| EP-2975037-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-20 | — | — | EP | disclosed |
| EP-2975037-A1 | BENZOTHIOPHENE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2016-01-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024060-A1 | BENZOTHIOPHENE DERIVATIVE | PDE10A, PDE5A, PDE3B | CD274 4685/4885PDCD1LG2 4520/4885PDE10A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.