Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL2 | P60568 | 9/20 | 0.36 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.34 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.34 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.34 |
| ▸ | TRPM4 | Q8TD43 | 1/20 | 0.34 |
| ▸ | PORCN | Q9H237 | 1/20 | 0.32 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.31 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.31 |
| ▸ | WNT3A | P56704 | 1/20 | 0.30 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.30 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17435136 | 0.92 | IL2 (0.42) | IL2PORCNMAP4K1WNT3APIK3C3 | |
| SCHEMBL14562874 | 0.91 | PORCN (0.39) | IL2TRPM4PORCNMAP4K1AAK1 | |
| SCHEMBL17435132 | 0.88 | IL2 (0.35) | IL2STIM1ORAI1ORAI2BACE1 | |
| SCHEMBL8258395 | 0.85 | POLB (0.42) | IL2STIM1ORAI1ORAI2HTT | |
| SCHEMBL17435135 | 0.85 | IL2 (0.36) | IL2STIM1ORAI1ORAI2KMT2A | |
| SCHEMBL17435130 | 0.85 | STIM1 (0.36) | IL2STIM1ORAI1ORAI2PORCN | |
| SCHEMBL14562873 | 0.84 | IL2 (0.42) | IL2PORCNMAP4K1AAK1WNT3A | |
| SCHEMBL17435137 | 0.80 | AGPAT2 (0.41) | IL2STIM1ORAI1ORAI2HTT | |
| SCHEMBL17435148 | 0.80 | IL2 (0.40) | IL2KMT2A | |
| SCHEMBL8259711 | 0.77 | IL2 (0.46) | IL2MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848435-B1 | COMPOUNDS AGAINST INFLAMMATIONS AND IMMUNE-RELATED USES | SYNTA PHARMACEUTICALS CORP (US) | 2016-01-20 | — | — | EP | claimed |