Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 10/20 | 0.39 |
| ▸ | S1PR5 | Q9H228 | 5/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 4/20 | 0.39 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.35 |
| ▸ | SPHK2 | Q9NRA0 | 3/20 | 0.34 |
| ▸ | SPHK1 | Q9NYA1 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1336492 | 0.96 | S1PR1 (0.41) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL1337475 | 0.91 | S1PR1 (0.46) | S1PR1S1PR5S1PR3S1PR4FFAR1 | |
| SCHEMBL1337453 | 0.91 | NPC1 (0.39) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL1338576 | 0.87 | S1PR1 (0.40) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL12129820 | 0.85 | ALDH1A1 (0.42) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL1744007 | 0.83 | TPH1 (0.36) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL1338057 | 0.83 | S1PR1 (0.46) | S1PR1S1PR5S1PR3ALDH1A1 | |
| SCHEMBL1337394 | 0.83 | S1PR1 (0.42) | S1PR1S1PR5S1PR3S1PR4ALDH1A1 | |
| SCHEMBL1336483 | 0.79 | S1PR1 (0.52) | S1PR1S1PR5S1PR3 | |
| SCHEMBL1337953 | 0.79 | S1PR1 (0.46) | S1PR1S1PR5S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2387571-A1 | OXADIAZOLE DERIVATIVES AS SLPL RECEPTOR AGONISTS | Almirall S.A. (ES) | 2011-11-23 | — | — | EP | disclosed |
| US-8041930-B2 | Data processing apparatus and method for controlling thread access of register sets when selectively operating in secure and non-secure domains | ARM LIMITED (GB) | 2011-10-18 | — | — | US | disclosed |
| WO-2010081692-A1 | OXADIAZOLE DERIVATIVES AS SLPL RECEPTOR AGONISTS | ALMIRALL, S.A. (ES) | 2010-07-22 | — | — | WO | disclosed |