Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.77 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.77 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.77 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.77 |
| ▸ | RELA | Q04206 | 5/20 | 0.77 |
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | NPC1 | O15118 | 8/20 | 0.64 |
| ▸ | RAB9A | P51151 | 8/20 | 0.64 |
| ▸ | HPGD | P15428 | 5/20 | 0.63 |
| ▸ | STAT1 | P42224 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | GAA | P10253 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | MITF | O75030 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21708400 | 0.92 | NPC1 (0.66) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL121572 | 0.87 | KDM4E (1.00) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL11562017 | 0.86 | KDM4E (0.61) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL8534417 | 0.86 | MAPT (0.79) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL11567645 | 0.86 | RAB9A (0.68) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL26962452 | 0.86 | NPC1 (0.61) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL31025226 | 0.86 | RAB9A (0.65) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL11561206 | 0.82 | SMN1; SMN2 (0.66) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL505728 | 0.82 | KDM4E (0.69) | SMN1; SMN2KDM4ENFKB1NFKB2RELA | |
| SCHEMBL11141442 | 0.82 | NPC1 (0.57) | SMN1; SMN2KDM4ENFKB1NFKB2RELA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024153226-A1 | PYRAZOLE-FUSED CYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION AND USE THEREOF | 北京普祺医药科技股份有限公司 | 2024-07-25 | — | — | WO | disclosed |
| CN-109180590-A | A method of Benzoheterocyclic compounds are quickly prepared using physical grinding method under room temperature solvent-free | 福建医科大学 | 2019-01-11 | — | — | CN | disclosed |
| US-8592467-B2 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. (US) | 2013-11-26 | — | — | US | disclosed |
| EP-2386556-B1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBVIE INC (US) | 2013-10-23 | — | — | EP | disclosed |
| EP-1926729-B1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LAB (US) | 2011-12-21 | — | — | EP | disclosed |
| EP-2386556-A1 | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | Abbott Laboratories (US) | 2011-11-16 | — | — | EP | disclosed |
| US-20110254413-A1 | CASING OF ELECTRONIC DEVICE AND MANUFACTURING METHOD THEREOF | ASUSTEK COMPUTER INC. (TW) | 2011-10-20 | — | — | US | disclosed |
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | ABBOTT LABORATORIES (US) | 2009-12-31 | — | — | US | disclosed |
| US-7576110-B2 | Benzothiazole cyclobutyl amine derivatives | ABBOTT LABORATORIES (US) | 2009-08-18 | — | — | US | disclosed |
| CN-101312966-A | Benzothiazole cyclobutyl amine derivatives and their use as histamine-3 receptors ligands | ABBOTT LAB (US) | 2008-11-26 | — | — | CN | disclosed |
| EP-1926729-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007038074-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES AND THEIR USE AS HISTAMINE-3 RECEPTORS LIGANDS | ABBOTT LABORATORIES (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | ABBVIE INC. | 2007-03-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326222-A1 | BENZOTHIAZOLE CYCLOBUTYL AMINE DERIVATIVES | HRH2, HRH4, HRH1 | SMN1; SMN2 3835/4885KDM4E 3229/4885NFKB1 2442/4885 |
| US-20070066588-A1 | Benzothiazole cyclobutyl amine derivatives | HRH2, HRH4, HRH1 | SMN1; SMN2 3835/4885KDM4E 3229/4885NFKB1 2442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.