Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
| ▸ | KDM5A | P29375 | 2/20 | 0.36 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.36 |
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TPH1 | P17752 | 1/20 | 0.36 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17443082 | 0.80 | LMNA (0.40) | LMNACAPN1EGLN1PLA2G10PLA2G2A | |
| SCHEMBL7138981 | 0.76 | PLA2G10 (0.45) | LMNAPLA2G10PLA2G2AKDM5AKDM4C | |
| SCHEMBL28954384 | 0.74 | PLA2G10 (0.44) | EGLN1PLA2G10PLA2G2ANR3C2KDM4E | |
| SCHEMBL2190828 | 0.74 | TP53 (0.40) | LMNAMEN1MAPTKMT2A | |
| SCHEMBL2884579 | 0.74 | IRAK4 (0.45) | LMNACAPN1ALDH1A1KDM4EMEN1 | |
| SCHEMBL30761115 | 0.74 | IRAK4 (0.45) | LMNACAPN1ALDH1A1KDM4EMEN1 | |
| SCHEMBL21438811 | 0.70 | ALDH1A1 (0.40) | LMNACAPN1ALDH1A1KDM4EMEN1 | |
| SCHEMBL21722361 | 0.70 | HCRTR2 (0.44) | LMNACAPN1KDM5BALDH1A1KDM4E | |
| SCHEMBL3462235 | 0.69 | PLA2G10 (0.50) | LMNAPLA2G10PLA2G2AALDH1A1NR3C2 | |
| SCHEMBL3544059 | 0.68 | NPC1 (0.49) | LMNAADRA1DALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016009297-A1 | PYRIDINE DERIVATIVES AS MUSCARINIC M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | PFIZER INC. (US) | 2016-01-21 | — | — | WO | disclosed |