Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | USP8 | P40818 | 1/20 | 0.33 |
| ▸ | USP5 | P45974 | 1/20 | 0.33 |
| ▸ | USP4 | Q13107 | 1/20 | 0.33 |
| ▸ | USP7 | Q93009 | 1/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28928746 | 0.84 | USP2 (0.39) | USP2USP8USP5USP4USP7 | |
| SCHEMBL221209 | 0.75 | — | — | |
| SCHEMBL14920453 | 0.75 | RECQL (0.44) | HTTUSP2GAAMAPTKDM4E | |
| SCHEMBL8687439 | 0.74 | MEN1 (0.32) | HTTMAPTKDM4EMEN1KMT2A | |
| SCHEMBL5775562 | 0.74 | KDM4E (0.47) | HTTGAAKDM4EEGLN2MEN1 | |
| SCHEMBL16992916 | 0.74 | KHK (0.36) | USP2USP8USP5USP4USP7 | |
| SCHEMBL19837522 | 0.74 | MBOAT4 (0.37) | MAPTKDM4EEGLN2HPGDSMN1; SMN2 | |
| SCHEMBL10614252 | 0.73 | KDM4E (0.30) | GAAMAPTKDM4E | |
| SCHEMBL7136171 | 0.71 | HTR6 (0.71) | USP2HTR6KDM4EMEN1KMT2A | |
| SCHEMBL25308965 | 0.71 | TAAR1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016011390-A1 | IRAK4 INHIBITING AGENTS | BIOGEN MA INC. (US) | 2016-01-21 | — | — | WO | disclosed |