Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B13 | Q7Z5P4 | 8/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | AKR1B10 | O60218 | 5/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17449511 | 0.91 | HPGD (0.40) | HSD17B13HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17449507 | 0.88 | HPGD (0.38) | HSD17B13HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL17449523 | 0.87 | ELANE (0.42) | HSD17B13HPGDCYP1A2CYP3A4CYP2C19 | |
| SCHEMBL15840305 | 0.80 | PDE7A (0.33) | HSD17B13HPGDALDH1A1KDM4EELANE | |
| SCHEMBL15840328 | 0.76 | AKR1B10 (0.38) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17449521 | 0.76 | ACSS2 (0.41) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL17449514 | 0.76 | CYP1A2 (0.37) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL15840333 | 0.72 | KDM4E (0.39) | HPGDCYP1A2CYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL16310703 | 0.71 | MPO (0.40) | HPGDALDH1A1KDM4EAKR1B10MAPT | |
| SCHEMBL15840325 | 0.69 | PARP1 (0.35) | HSD17B13HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160016915-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | GILEAD CALISTOGA LLC. | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016915-A1 | PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS | PIK3R5, PIK3CA, PIK3R4 | HSD17B13 1309/4885HPGD 3137/4885CYP1A2 1728/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.