Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 2/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | TTR | P02766 | 1/20 | 0.37 |
| ▸ | APP | P05067 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | TYR | P14679 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | GPER1 | Q99527 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1745234 | 1.00 | CCR2 (0.42) | CCR2PIN1SMN1; SMN2FFAR1IDO1 | |
| SCHEMBL4261410 | 0.88 | CCR2 (0.42) | CCR2PIN1SMN1; SMN2FFAR1IDO1 | |
| SCHEMBL4261413 | 0.88 | CCR2 (0.42) | CCR2PIN1SMN1; SMN2FFAR1IDO1 | |
| SCHEMBL1745236 | 0.79 | AKR1C3 (0.40) | PIN1FFAR1IDO1TUBB1GFRA2 | |
| SCHEMBL1744713 | 0.76 | PIN1 (0.40) | PIN1SMN1; SMN2FFAR1IDO1KDM4E | |
| SCHEMBL12320178 | 0.76 | IDO1 (0.51) | PIN1FFAR1IDO1 | |
| SCHEMBL1745233 | 0.75 | FFAR1 (0.40) | PIN1FFAR1IDO1GFRA2GFRA3 | |
| SCHEMBL1746749 | 0.73 | IDO1 (0.49) | PIN1FFAR1IDO1 | |
| SCHEMBL1746491 | 0.72 | FFAR1 (0.43) | PIN1FFAR1IDO1 | |
| SCHEMBL2439707 | 0.71 | CA12 (0.53) | SMN1; SMN2KDM4EKMT2ATTRAPP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2385032-A1 | GPR40 Receptor function regulator | Takeda Pharmaceutical Company Limited (JP) | 2011-11-09 | — | — | EP | disclosed |
| US-8008525-B2 | For the 14273 peroxisome proliferator activated receptor; antidiabetic agents, hyperlipidemia, obesity or anorexia; receptor binding assay; drug screening kits | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-08-30 | — | — | US | disclosed |
| US-7960369-B2 | Receptor function regulator | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-14 | — | — | US | disclosed |