Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | BMPR1B | O00238 | 5/20 | 0.39 |
| ▸ | BMPR1A | P36894 | 5/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.39 |
| ▸ | ACVRL1 | P37023 | 5/20 | 0.39 |
| ▸ | ACVR1 | Q04771 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22822278 | 0.87 | MEN1 (0.40) | MEN1KMT2ALMNABMPR1BBMPR1A | |
| SCHEMBL6124250 | 0.86 | MEN1 (0.51) | MEN1KMT2ALMNANR1H3BMPR1B | |
| SCHEMBL12546173 | 0.85 | TRIM24 (0.43) | NR1H3HPGDGFERHSD17B10TRIM24 | |
| SCHEMBL15625470 | 0.81 | BMPR1B (0.40) | MEN1KMT2AHPGDGFERHSD17B10 | |
| SCHEMBL26141146 | 0.79 | NR1H3 (0.39) | LMNANR1H3HPGDGFERHSD17B10 | |
| SCHEMBL19910563 | 0.79 | BRD4 (0.49) | MEN1KMT2AHPGDGFERHSD17B10 | |
| SCHEMBL1102435 | 0.78 | HSP90AA1 (0.41) | MEN1KMT2ALMNANR1H3HPGD | |
| SCHEMBL5986263 | 0.77 | HSD17B10 (0.47) | MEN1KMT2AHPGDHSD17B10BMPR1B | |
| SCHEMBL23349373 | 0.76 | CTSC (0.41) | MEN1KMT2ALMNABMPR1BBMPR1A | |
| SCHEMBL11032224 | 0.75 | DRD2 (0.44) | BMPR1BBMPR1AACVRL1ACVR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230121807-A1 | NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF | HAISCO PHARMACEUTICALS PTE. LTD (SG) | 2023-04-20 | — | — | US | disclosed |
| WO-2021155320-A1 | COMPOUNDS AND USES THEREOF | FOGHORN THERAPEUTICS INC. (US) | 2021-08-05 | — | — | WO | disclosed |
| WO-2018048928-A1 | CHEMICAL PROBES OF LYSYL OXIDASE-LIKE 2 AND USES THEREOF | PHARMAKEA, INC. (US) | 2018-03-15 | — | — | WO | disclosed |
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | MERCK PATENT GMBH (DE) | 2016-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160016951-A1 | NOVEL NAPHTHYRIDINES AND ISOQUINOLINES AND THEIR USE AS CDK8/19 INHIBITORS | CDK8, CDK9, CDK18 | MEN1 3239/4885KMT2A 248/4885LMNA 1389/4885 |
| US-20230121807-A1 | NITRILE DERIVATIVE THAT ACTS AS INHIBITOR OF DIPEPTIDYL PEPTIDASE 1 AND USE THEREOF | DPP4, DPP3, DPP9 | MEN1 3665/4885KMT2A 4601/4885LMNA 4224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.