Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.54 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.52 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17453383 | 0.81 | UTS2R (0.56) | UTS2RERBB2PTK6RXFP1KDM4E | |
| SCHEMBL16011809 | 0.76 | ALK (0.54) | UTS2RERBB2PTK6EGFR | |
| SCHEMBL675163 | 0.74 | PTK6 (0.59) | UTS2RERBB2PTK6CHUKEGFR | |
| SCHEMBL20462060 | 0.74 | IGF1R (0.39) | UTS2RERBB2PTK6EGFRIGF1R | |
| SCHEMBL23606151 | 0.73 | CHUK (0.42) | ERBB2PTK6CHUKRXFP1CCNB2 | |
| SCHEMBL6881920 | 0.73 | AURKA (0.56) | UTS2RCHUKMAP2K7EGFRIGF1R | |
| SCHEMBL31219008 | 0.73 | AURKA (0.56) | UTS2RCHUKMAP2K7EGFRIGF1R | |
| SCHEMBL30273621 | 0.73 | CHUK (0.54) | UTS2RERBB2PTK6CHUKCCNB2 | |
| SCHEMBL16011911 | 0.73 | CHUK (0.54) | UTS2RERBB2PTK6CHUKCCNB2 | |
| SCHEMBL23885518 | 0.72 | MAP2K7 (0.48) | UTS2RCHUKMAP2K7EGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11325908-B2 | CaMKII inhibitors and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2022-05-10 | — | — | US | disclosed |
| EP-3189052-B1 | CAMKII INHIBITORS AND USES THEREOF | UNIV JOHNS HOPKINS (US) | 2021-11-03 | — | — | EP | disclosed |
| EP-3189052-B1 | CAMKII INHIBITORS AND USES THEREOF | UNIV JOHNS HOPKINS (US) | 2021-11-03 | — | — | EP | disclosed |
| US-20200385383-A1 | CaMKII INHIBITORS AND USES THEREOF | ALLOSTEROS THERAPEUTICS, INC. | 2020-12-10 | — | — | US | disclosed |
| US-10759792-B2 | CaMKII inhibitors and uses thereof | THE JOHNS HOPKINS UNIVERSITY (US) | 2020-09-01 | — | — | US | disclosed |
| EP-2964225-B1 | CaMKII INHIBITORS AND USES THEREOF | ALLOSTEROS THERAPEUTICS INC (US) | 2018-08-08 | — | — | EP | disclosed |
| US-9951061-B2 | CaMKII inhibitors and uses thereof | ALLOSTEROS THERAPEUTICS, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| US-20170247374-A1 | CaMKII INHIBITORS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| US-20170247374-A1 | CaMKII INHIBITORS AND USES THEREOF | THE JOHNS HOPKINS UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| WO-2016037106-A1 | CaMKII INHIBITORS AND USES THEREOF | ALLOSTEROS THERAPEUTICS, INC (US) | 2016-03-10 | — | — | WO | disclosed |
| US-20160024078-A1 | CaMKII INHIBITORS AND USES THEREOF | ALLOSTEROS THERAPEUTICS, INC. (US) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11325908-B2 | CaMKII inhibitors and uses thereof | CAMK2G, CAMK2B, CAMK1 | UTS2R 4564/4885ERBB2 194/4885PTK6 273/4885 |
| US-20170247374-A1 | CaMKII INHIBITORS AND USES THEREOF | CAMK2G, CAMK2B, CAMK1 | UTS2R 4564/4885ERBB2 194/4885PTK6 273/4885 |
| US-20160024078-A1 | CaMKII INHIBITORS AND USES THEREOF | CAMK2G, CAMK2B, CAMK1 | UTS2R 4564/4885ERBB2 194/4885PTK6 273/4885 |
| US-20200385383-A1 | CaMKII INHIBITORS AND USES THEREOF | CAMK2G, CAMK2B, CAMK1 | UTS2R 4564/4885ERBB2 194/4885PTK6 273/4885 |
| US-10759792-B2 | CaMKII inhibitors and uses thereof | CAMK2G, CAMK2B, CAMK1 | UTS2R 4564/4885ERBB2 194/4885PTK6 273/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.