SCHEMBL1745481

SCHEMBL1745481

CCCN(Cc1ccc(COc2ccc(CCC(=O)OC)cc2)cc1)c1nc(-c2ccccc2)cs1

nearest known ligand 0.47

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
NPSR1 Q6W5P4 2/20 0.47
KMT2A Q03164 4/20 0.46
MEN1 O00255 3/20 0.46
FFAR1 O14842 2/20 0.46
MAPT P10636 3/20 0.45
HTT P42858 1/20 0.45
ATP4A P20648 2/20 0.44
ATP4B P51164 2/20 0.44
PPARD Q03181 4/20 0.44
L3MBTL1 Q9Y468 1/20 0.44
GSTO1 P78417 1/20 0.44
ALDH1A1 P00352 1/20 0.43
PTPRB P23467 1/20 0.43
VDR P11473 1/20 0.43
BCHE P06276 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3917024 0.95 NPSR1 (0.53) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL1745386 0.93 ATP4A (0.45) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL1745444 0.93 KMT2A (0.48) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL1745053 0.92 FFAR1 (0.53) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL1744677 0.91 FFAR1 (0.47) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL1745729 0.90 PPARD (0.49) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL3913216 0.90 FFAR1 (0.57) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL3911602 0.90 NPSR1 (0.51) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL3912168 0.89 PPARD (0.44) NPSR1KMT2AMEN1FFAR1MAPT
SCHEMBL3912639 0.89 PPARD (0.44) NPSR1KMT2AMEN1FFAR1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR NPSR1 132/4885KMT2A 4408/4885MEN1 2579/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.