SCHEMBL17455196

SCHEMBL17455196

CC(C(=O)O)c1ccc(NCc2cccc(Oc3ccccc3)c2)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 18/20 1.00
GNA15 P30679 1/20 0.63
PTGER3 P43115 1/20 0.63
FFAR4 Q5NUL3 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
PTGS1 P23219 1/20 0.59
HIF1A Q16665 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30924433 1.00 FFAR1 (1.00) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL11804605 0.84 FFAR1 (0.71) FFAR1FFAR4PTGS1HIF1A
Propionic Acid SCHEMBL2305821 0.81 FFAR1 (0.74) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL4748821 0.81 FFAR1 (0.74) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL5180058 0.80 FFAR1 (0.66) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL14924230 0.78 FFAR1 (0.82) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL2305825 0.78 FFAR1 (0.68) FFAR1GNA15PTGER3FFAR4TDP1
SCHEMBL5859386 0.78 FFAR1 (0.64) FFAR1GNA15PTGER3FFAR4TDP1
Gw9508 SCHEMBL29766936 0.78 FFAR1 (1.00) FFAR1GNA15PTGER3FFAR4TDP1
Gw9508 SCHEMBL364468 0.78 FFAR1 (1.00) FFAR1GNA15PTGER3FFAR4TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106998743-B Compounds for modulating fatty acid receptor activity and pet food comprising the same 马斯公司 2024-05-24 CN disclosed
CN-106715409-B Complex preparation for preventing or treating metabolic diseases comprising 3- (4- (benzyloxy) phenyl) -4-hexynoic acid derivative and other active ingredients 现代药品株式会社 2020-09-11 CN disclosed
CN-111423408-A Compound preparation for preventing or treating metabolic diseases 现代药品株式会社 2020-07-17 CN disclosed
EP-2987791-B1 3-(4-(BENZYLOXY)PHENYL)HEX-4-INOIC ACID DERIVATIVE, SUITABLE FOR PREVENTING AND TREATING METABOLIC DISEASES HYUNDAI PHARM CO LTD (KR) 2019-07-17 EP disclosed
US-9969723-B2 3-(4-(benzyloxy)phenyl)hex-4-ynoic acid derivative, method of preparing same and pharmaceutical composition for preventing and treating metabolic disease including same as effective ingredient HYUNDAI PHARM CO., LTD (KR) 2018-05-15 US disclosed
CN-105121423-B 3- (4- (benzyloxy) phenyl) hex-4-ynoic acid derivative, method for preparing the same, and pharmaceutical composition for preventing and treating metabolic diseases comprising the same as an effective ingredient 现代药品株式会社 2017-06-09 CN disclosed
CN-106715409-A Complex preparation for preventing or treating metabolic diseases comprising novel 3- (4- (benzyloxy) phenyl) -4-hexenoic acid derivative and other active ingredients 现代药品株式会社 2017-05-24 CN disclosed
EP-2987791-A1 NOVEL 3-(4-(BENZYLOXY)PHENYL)HEX-4-INOIC ACID DERIVATIVE, METHOD OF PREPARING SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASE INCLUDING SAME AS EFFECTIVE INGREDIENT Hyundai Pharm Co., Ltd. (KR) 2016-02-24 EP disclosed
US-20160024063-A1 NOVEL 3-(4(BENZYLOXY)PHENYL)HEX-4-INOIC ACID DERIVATIVE, METHOD OF PREPARING SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASE INCLUDING SAME AS EFFECTIVE INGREDIENT HYUNDAI PHARM CO., LTD (KR) 2016-01-28 US disclosed
CN-103980235-A GPR120 receptor agonists and uses thereof CYMABAY THERAPEUTICS INC 2014-08-13 CN disclosed
CN-102307860-B GPR120 receptor agonists and uses thereof METABOLEX INC 2014-07-02 CN disclosed
CN-102307860-A GPR120 receptor agonists and uses thereof METABOLEX INC 2012-01-04 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160024063-A1 NOVEL 3-(4(BENZYLOXY)PHENYL)HEX-4-INOIC ACID DERIVATIVE, METHOD OF PREPARING SAME AND PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING METABOLIC DISEASE INCLUDING SAME AS EFFECTIVE INGREDIENT GPR119, INSR, IRS1 FFAR1 5/4885GNA15 1255/4885PTGER3 2417/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.