Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 11/20 | 0.46 |
| ▸ | SYK | P43405 | 7/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.39 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161218 | 0.90 | DGAT1 (0.56) | DGAT1 | |
| SCHEMBL173719 | 0.85 | DGAT1 (0.40) | DGAT1XDHSLC22A12LMNA | |
| SCHEMBL160753 | 0.80 | DGAT1 (0.52) | DGAT1LMNA | |
| SCHEMBL174323 | 0.80 | DGAT1 (0.57) | DGAT1 | |
| SCHEMBL162401 | 0.80 | DGAT1 (0.58) | DGAT1SYK | |
| SCHEMBL173720 | 0.79 | DGAT1 (0.56) | DGAT1LMNA | |
| SCHEMBL161973 | 0.79 | DGAT1 (0.69) | DGAT1 | |
| SCHEMBL161415 | 0.77 | DGAT1 (0.58) | DGAT1 | |
| SCHEMBL174631 | 0.77 | KMT2A (0.50) | LMNA | |
| SCHEMBL160006 | 0.75 | DGAT1 (0.56) | DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |