Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | TP53 | P04637 | 6/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.45 |
| ▸ | CA2 | P00918 | 2/20 | 0.45 |
| ▸ | CA9 | Q16790 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 5/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164685 | 0.90 | KMT2A (0.52) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL174086 | 0.85 | KMT2A (0.49) | KMT2ATP53NPC1CA12CA1 | |
| SCHEMBL164651 | 0.80 | KMT2A (0.50) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL173260 | 0.80 | TP53 (0.52) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL174087 | 0.79 | KMT2A (0.53) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL162433 | 0.79 | NPC1 (0.57) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL437870 | 0.79 | CYP2C9 (0.58) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL406907 | 0.79 | CYP2C9 (0.58) | KMT2ATP53CYP2C9HDAC4NPC1 | |
| SCHEMBL174317 | 0.79 | S1PR4 (0.49) | KMT2ATP53CYP2C9NPC1CA12 | |
| SCHEMBL174328 | 0.79 | S1PR4 (0.49) | KMT2ATP53CYP2C9NPC1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |