Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 2/20 | 0.56 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL161218 | 0.90 | DGAT1 (0.56) | DGAT1TRPV1 | |
| SCHEMBL160753 | 0.88 | DGAT1 (0.52) | DGAT1TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL173719 | 0.86 | DGAT1 (0.40) | DGAT1TRPV1LMNA | |
| SCHEMBL174553 | 0.79 | DGAT1 (0.46) | DGAT1LMNA | |
| SCHEMBL174087 | 0.78 | KMT2A (0.53) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL162577 | 0.76 | DGAT1 (0.56) | DGAT1 | |
| SCHEMBL161827 | 0.76 | DGAT1 (0.47) | DGAT1 | |
| SCHEMBL158327 | 0.76 | DGAT1 (0.47) | DGAT1 | |
| SCHEMBL165688 | 0.75 | DGAT1 (0.60) | DGAT1TRPV1HDAC3HDAC11HDAC8 | |
| SCHEMBL161479 | 0.75 | NR1H4 (0.61) | DGAT1TRPV1HDAC3HDAC11HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |