Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | IDO1 | P14902 | 1/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.65 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.65 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | CASP3 | P42574 | 1/20 | 0.59 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.59 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.59 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17457487 | 1.00 | HDAC6 (0.65) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL17457464 | 0.88 | TRPA1 (0.64) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL17457462 | 0.88 | TRPA1 (0.64) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL6887653 | 0.82 | MAPT (0.62) | HDAC6HDAC8HDAC1HDAC2TRPA1 | |
| SCHEMBL301050 | 0.82 | TRPA1 (0.62) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL301051 | 0.82 | MAPT (0.62) | HDAC6HDAC8HDAC1HDAC2TRPA1 | |
| SCHEMBL12620628 | 0.82 | HDAC6 (0.77) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL20194015 | 0.81 | PTPN1 (0.67) | HDAC6HDAC8HDAC1HDAC2HDAC3 | |
| SCHEMBL14130013 | 0.81 | MAPT (0.68) | HDAC6HDAC8HDAC2TRPA1MAPT | |
| SCHEMBL17472006 | 0.81 | PTPN1 (0.67) | HDAC6HDAC8HDAC1HDAC2HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970107-B1 | PHOTOSWITCHABLE HDAC INHIBITORS | MASSACHUSETTS GEN HOSPITAL (US) | 2023-11-15 | — | — | EP | disclosed |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2023-03-07 | — | — | US | disclosed |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2021-06-03 | — | — | US | disclosed |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2020-11-10 | — | — | US | disclosed |
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION | 2019-03-07 | — | — | US | disclosed |
| US-9981038-B2 | Photoswitchable HDAC inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2018-05-29 | — | — | US | disclosed |
| US-20160022817-A1 | Photoswitchable HDAC Inhibitors | THE GENERAL HOSPITAL CORPORATION (US) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190070295-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | HDAC6 10/4885HDAC8 4/4885HDAC1 2/4885 |
| US-20160022817-A1 | Photoswitchable HDAC Inhibitors | HDAC1, HDAC4, HDAC3 | HDAC6 10/4885HDAC8 5/4885HDAC1 1/4885 |
| US-20210162048-A1 | Photoswitchable HDAC Inhibitors | HDAC4, HDAC1, HDAC3 | HDAC6 10/4885HDAC8 4/4885HDAC1 2/4885 |
| US-11596691-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | HDAC6 10/4885HDAC8 4/4885HDAC1 2/4885 |
| US-10828367-B2 | Photoswitchable HDAC inhibitors | HDAC4, HDAC1, HDAC3 | HDAC6 10/4885HDAC8 4/4885HDAC1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.