Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15813965 | 0.86 | SLC22A12 (0.40) | TTRESRRAMAPTALDH1A1TSHR | |
| SCHEMBL14662745 | 0.85 | SLC22A12 (0.42) | TTRESRRAMAPTALDH1A1SLC22A12 | |
| SCHEMBL876021 | 0.82 | ALDH1A1 (0.42) | TTRESRRAMAPTALDH1A1TSHR | |
| SCHEMBL15832083 | 0.82 | TTR (0.43) | TTRESRRAMAPTALDH1A1TSHR | |
| SCHEMBL31276992 | 0.81 | CYP3A4 (0.41) | ESRRAAAK1CYP3A4SLC22A12AR | |
| SCHEMBL14663488 | 0.81 | CYP3A4 (0.41) | ESRRAAAK1CYP3A4SLC22A12AR | |
| SCHEMBL9889480 | 0.79 | AR (0.56) | TTRESRRAALDH1A1TSHRAR | |
| SCHEMBL17467724 | 0.77 | AR (0.49) | TTRGRM2AAK1CYP3A4AR | |
| SCHEMBL9889474 | 0.77 | PLA2G7 (0.51) | TTRESRRASLC22A12AR | |
| SCHEMBL17460333 | 0.77 | MAPT (0.47) | TTRESRRAMAPTALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016012916-A1 | 1,2,3,5-TETRAHYDROIMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES AND DISORDERS MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-01-28 | — | — | WO | disclosed |
| WO-2016012916-A1 | 1,2,3,5-TETRAHYDROIMIDAZO[1,2-C]PYRIMIDINE DERIVATIVES USEFUL IN THE TREATMENT OF DISEASES AND DISORDERS MEDIATED BY LP-PLA2 | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2016-01-28 | — | — | WO | disclosed |