Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGF1 | P05230 | 2/20 | 0.36 |
| ▸ | HPSE | Q9Y251 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25505092 | 1.00 | FGF1 (0.36) | FGF1HPSE | |
| SCHEMBL11997774 | 1.00 | FGF1 (0.36) | FGF1HPSE | |
| SCHEMBL19978395 | 1.00 | FGF1 (0.36) | FGF1HPSE | |
| SCHEMBL12534502 | 0.94 | FGF1 (0.35) | FGF1HPSE | |
| SCHEMBL17035801 | 0.94 | FGF1 (0.35) | FGF1HPSE | |
| SCHEMBL13548842 | 0.94 | FGF1 (0.35) | FGF1HPSE | |
| SCHEMBL17035791 | 0.89 | FGF1 (0.35) | FGF1HPSE | |
| SCHEMBL12534508 | 0.84 | G6PD (0.38) | FGF1HPSE | |
| SCHEMBL17035820 | 0.83 | FGF1 (0.33) | FGF1HPSE | |
| SCHEMBL16769171 | 0.82 | G6PD (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170253584-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | GILEAD PHARMASSET LLC (US) | 2017-09-07 | — | — | US | disclosed |
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | PHARMASSET, INC. | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024061-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | FGF1 3482/4885HPSE 1467/4885 |
| US-20170253584-A1 | PREPARATION OF 2'-FLUORO-2'-ALKYL-SUBSTITUTED OR OTHER OPTIONALLY SUBSTITUTED RIBOFURANOSYL PYRIMIDINES AND PURINES AND THEIR DERIVATIVES | NSUN2, FBL, RNGTT | FGF1 3407/4885HPSE 1368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.