Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL164685 | 0.90 | KMT2A (0.52) | KMT2ATP53TRPV1LMNAMAPT | |
| SCHEMBL164651 | 0.88 | KMT2A (0.50) | KMT2ATP53TRPV1LMNAMAPT | |
| SCHEMBL174086 | 0.86 | KMT2A (0.49) | KMT2ATP53LMNAMAPTNPC1 | |
| SCHEMBL174631 | 0.79 | KMT2A (0.50) | KMT2ATP53LMNAMAPTCYP2C9 | |
| SCHEMBL173720 | 0.78 | DGAT1 (0.56) | TRPV1LMNAHDAC3HDAC11HDAC8 | |
| SCHEMBL23657595 | 0.75 | NPC1 (0.53) | KMT2ATP53LMNAMAPTCYP2C9 | |
| SCHEMBL162045 | 0.73 | TRPV1 (0.49) | TRPV1HDAC3HDAC11HDAC8HDAC6 | |
| SCHEMBL14758420 | 0.72 | KMT2A (0.54) | KMT2ATP53LMNAMAPTCYP2C9 | |
| SCHEMBL162967 | 0.71 | TRPV1 (0.47) | TRPV1LMNAMAPTHDAC3HDAC11 | |
| SCHEMBL22274770 | 0.71 | KMT2A (0.53) | KMT2ATP53LMNAMAPTCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |