Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 5/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL174087 | 0.86 | KMT2A (0.53) | KMT2ATP53NPC1RAB9AMAPT | |
| SCHEMBL174631 | 0.85 | KMT2A (0.50) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL164685 | 0.76 | KMT2A (0.52) | KMT2ATP53NPC1MAPTLMNA | |
| SCHEMBL164651 | 0.74 | KMT2A (0.50) | KMT2ATP53NPC1RAB9ANOD2 | |
| SCHEMBL173719 | 0.74 | DGAT1 (0.40) | LMNA | |
| SCHEMBL12498922 | 0.69 | CA12 (0.61) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL19399052 | 0.68 | NPC1 (0.62) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL19366465 | 0.66 | HDAC4 (0.65) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL12499755 | 0.66 | CA12 (0.57) | KMT2ACA12CA1CA2CA9 | |
| SCHEMBL2957181 | 0.66 | KIF11 (0.57) | KMT2ANPC1RAB9AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2611783-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | Piramal Enterprises Limited (IN) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012029032-A2 | HETEROCYCLIC COMPOUNDS AS DGAT1 INHIBITORS | PIRAMAL LIFE SCIENCES LIMITED (IN) | 2012-03-08 | — | — | WO | disclosed |