SCHEMBL1746407

SCHEMBL1746407

O=C(O)COc1ccc(OC2CCc3ccccc32)cc1

nearest known ligand 0.60

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 6/20 0.60
ALOX15 P16050 2/20 0.50
PTPN7 P35236 2/20 0.46
MEN1 O00255 1/20 0.46
ALDH1A1 P00352 1/20 0.46
MAPT P10636 1/20 0.46
KMT2A Q03164 1/20 0.46
PTPN12 Q05209 1/20 0.46
IDO1 P14902 2/20 0.45
TAOK1 Q7L7X3 2/20 0.45
TAOK3 Q9H2K8 1/20 0.44
PTGDR2 Q9Y5Y4 1/20 0.44
TSHR P16473 1/20 0.43
HSD17B10 Q99714 1/20 0.43
PPARD Q03181 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1746615 0.84 FFAR1 (0.60) FFAR1ALDH1A1IDO1TSHR
SCHEMBL1633344 0.82 FFAR1 (0.57) FFAR1
SCHEMBL1633343 0.82 FFAR1 (0.57) FFAR1
SCHEMBL1745432 0.82 FFAR1 (0.57) FFAR1
SCHEMBL12017975 0.81 IDO1 (0.61) FFAR1IDO1
SCHEMBL30639030 0.80 IDO1 (0.53) FFAR1IDO1PTGDR2
SCHEMBL2092235 0.80 IDO1 (0.53) FFAR1IDO1PTGDR2
SCHEMBL1744683 0.79 FFAR1 (0.72) FFAR1
SCHEMBL1744694 0.79 FFAR1 (0.72) FFAR1
SCHEMBL8529487 0.78 IDO1 (0.54) FFAR1IDO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885ALOX15 3368/4885PTPN7 1239/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.