Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.30 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.30 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.30 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.30 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5677899 | 0.82 | TSHR (0.50) | TSHR | |
| SCHEMBL5675923 | 0.77 | TSHR (0.46) | TSHR | |
| SCHEMBL9521759 | 0.77 | TSHR (0.46) | TSHR | |
| SCHEMBL17464918 | 0.74 | TSHR (0.39) | TSHRCYP2C19 | |
| SCHEMBL1615096 | 0.74 | TSHR (0.37) | TSHRCYP2C19 | |
| SCHEMBL15698229 | 0.74 | TSHR (0.37) | TSHRCYP2C19 | |
| SCHEMBL10894349 | 0.73 | TSHR (0.42) | TSHR | |
| SCHEMBL9788184 | 0.70 | TSHR (0.33) | TSHR | |
| SCHEMBL16934711 | 0.70 | TSHR (0.43) | TSHRCYP2C19GRIN1GRIN2AGRIN2D | |
| SCHEMBL12014993 | 0.70 | TSHR (0.50) | TSHRCYP2C19GRIN1GRIN2AGRIN2D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550763-B2 | Heterocyclic ring and carbocyclic derivative | SHIONOGI & CO., LTD. (JP) | 2017-01-24 | — | — | US | disclosed |
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | SHIONOGI & CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | P2RX3, P2RX7, P2RX2 | TSHR 737/4885CYP2C19 524/4885GRIN1 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.