Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | APAF1 | O14727 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | UBE2N | P61088 | 1/20 | 0.39 |
| ▸ | RGS4 | P49798 | 1/20 | 0.39 |
| ▸ | RGS8 | P57771 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15215745 | 0.78 | ALDH1A1 (0.52) | KDM4EP2RX3THRBALDH1A1GAA | |
| SCHEMBL17464948 | 0.78 | P2RX3 (0.47) | KDM4EP2RX3BRD4THRBAPAF1 | |
| SCHEMBL17464946 | 0.78 | P2RX3 (0.48) | KDM4EP2RX3BRD4THRBAPAF1 | |
| SCHEMBL17879620 | 0.74 | P2RX3 (0.49) | KDM4EP2RX3BRD4ALDH1A1GAA | |
| SCHEMBL15015882 | 0.71 | ATM (0.47) | KDM4EP2RX3ALDH1A1GAAPOLB | |
| SCHEMBL27864221 | 0.66 | ALDH1A1 (0.51) | KDM4EBRD4ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL11719377 | 0.64 | P2RX3 (0.54) | KDM4EP2RX3THRBALDH1A1POLB | |
| SCHEMBL28070652 | 0.64 | TP53 (0.65) | APAF1ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL11460374 | 0.63 | MEN1 (0.60) | KDM4EALDH1A1GAAPOLBMAPT | |
| Hydrochloric Acid SCHEMBL1047768 | 0.62 | BRD4 (0.43) | BRD4SMN1; SMN2LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9550763-B2 | Heterocyclic ring and carbocyclic derivative | SHIONOGI & CO., LTD. (JP) | 2017-01-24 | — | — | US | disclosed |
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | SHIONOGI & CO., LTD. (JP) | 2016-01-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160024072-A1 | Heterocyclic Ring and Carbocyclic Derivative | P2RX3, P2RX7, P2RX2 | KDM4E 3118/4885P2RX3 1/4885BRD4 803/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.