SCHEMBL1746572

SCHEMBL1746572

COC(=O)CCc1ccc(OCc2ccc(Oc3ccc(-c4ccccc4)cc3)cc2)cc1

nearest known ligand 0.69

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 13/20 0.69
FFAR4 Q5NUL3 5/20 0.65
AKR1B1 P15121 1/20 0.56
ACACB O00763 1/20 0.54
PPARG P37231 1/20 0.51
MMP12 P39900 1/20 0.51
ADAMTS4 O75173 1/20 0.51
GSTP1 P09211 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1744673 0.96 FFAR1 (0.74) FFAR1FFAR4AKR1B1MMP12GSTP1
SCHEMBL1745237 0.93 FFAR1 (0.70) FFAR1FFAR4AKR1B1PPARG
SCHEMBL1746671 0.93 FFAR1 (0.74) FFAR1FFAR4PPARG
SCHEMBL1744585 0.93 FFAR1 (0.74) FFAR1FFAR4PPARG
SCHEMBL1747136 0.89 FFAR1 (0.72) FFAR1FFAR4AKR1B1
SCHEMBL1745247 0.89 FFAR1 (0.72) FFAR1FFAR4AKR1B1
SCHEMBL5927538 0.89 FFAR1 (0.64) FFAR1FFAR4MMP12
SCHEMBL1747197 0.87 FFAR1 (0.91) FFAR1FFAR4AKR1B1
SCHEMBL1744991 0.86 FFAR1 (0.77) FFAR1FFAR4AKR1B1
SCHEMBL14305720 0.85 FFAR1 (0.67) FFAR1FFAR4AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885AKR1B1 1186/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.