SCHEMBL17466006

SCHEMBL17466006

CCOC(=O)/C(C#N)=C\C=C(c1ccccc1)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 11/20 0.52
DHODH Q02127 1/20 0.52
TP53 P04637 1/20 0.52
POLB P06746 1/20 0.51
TDP1 Q9NUW8 1/20 0.51
RAB9A P51151 6/20 0.51
SMN1; SMN2 Q16637 6/20 0.51
NPC1 O15118 5/20 0.51
NPSR1 Q6W5P4 3/20 0.51
ALDH1A1 P00352 7/20 0.50
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
USP2 O75604 2/20 0.50
GAA P10253 2/20 0.50
MAPK1 P28482 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
STAT1 P42224 1/20 0.50
PDCD1 Q15116 1/20 0.49
CD274 Q9NZQ7 1/20 0.49
ATM Q13315 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14163400 0.88 DNM1 (0.46) MAPTDHODHTP53POLBTDP1
SCHEMBL14017686 0.85 MAPT (0.41) MAPTDHODHTP53POLBTDP1
SCHEMBL1576722 0.84 POLB (0.46) MAPTPOLBTDP1ALDH1A1MEN1
SCHEMBL1576724 0.84 POLB (0.46) MAPTPOLBTDP1ALDH1A1MEN1
SCHEMBL14017685 0.83 MAOB (0.40) MAPTDHODHTP53POLBTDP1
SCHEMBL14017688 0.81 DNM1 (0.39) MAPTDHODHTP53POLBTDP1
SCHEMBL14156332 0.80 MEN1 (0.60) MAPTDHODHPOLBTDP1SMN1; SMN2
SCHEMBL14156466 0.80 MAOB (0.38) MAPTDHODHTP53POLBALDH1A1
SCHEMBL10399172 0.79 ALDH1A1 (0.51) MAPTTDP1SMN1; SMN2NPC1NPSR1
SCHEMBL10399175 0.79 ALDH1A1 (0.51) MAPTTDP1SMN1; SMN2NPC1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3172272-B1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & CO (US) 2020-11-25 EP disclosed
US-9410035-B2 Modified heterophasic polyolefin composition MILLIKEN & COMPANY (US) 2016-08-09 US disclosed
US-9410035-B2 Modified heterophasic polyolefin composition MILLIKEN & COMPANY (US) 2016-08-09 US disclosed
US-20160024289-A1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & COMPANY 2016-01-28 US disclosed
US-20160024289-A1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & COMPANY 2016-01-28 US disclosed
WO-2016014122-A1 MODIFIED HETEROPHASIC POLYOLEFIN COMPOSITION MILLIKEN & COMPANY (US) 2016-01-28 WO disclosed