SCHEMBL1746741

SCHEMBL1746741

CCCN(Cc1ccc(COc2ccc(CCC(=O)OCC)c(F)c2)cc1)c1nc(-c2ccccc2)cs1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 5/20 0.42
FFAR4 Q5NUL3 1/20 0.42
GSTO1 P78417 1/20 0.42
KMT2A Q03164 4/20 0.42
MEN1 O00255 3/20 0.42
NPSR1 Q6W5P4 2/20 0.42
PPARD Q03181 3/20 0.42
MMP13 P45452 1/20 0.42
MAPT P10636 3/20 0.41
HTT P42858 1/20 0.41
PARP1 P09874 1/20 0.41
PPARG P37231 1/20 0.40
PPARA Q07869 1/20 0.40
ALDH1A1 P00352 1/20 0.40
L3MBTL1 Q9Y468 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3912746 0.95 NPSR1 (0.45) FFAR1FFAR4GSTO1KMT2AMEN1
SCHEMBL15679197 0.95 FFAR1 (0.44) FFAR1FFAR4GSTO1KMT2AMEN1
SCHEMBL1745640 0.93 FFAR1 (0.50) FFAR1FFAR4PPARD
SCHEMBL3912187 0.92 FFAR1 (0.46) FFAR1FFAR4GSTO1KMT2AMEN1
SCHEMBL3922019 0.91 ALOX5 (0.47) FFAR1GSTO1PPARDPPARGPPARA
SCHEMBL3911680 0.89 ALOX5 (0.45) FFAR1KMT2AMEN1NPSR1PPARD
SCHEMBL3912498 0.87 KMT2A (0.45) FFAR1GSTO1KMT2AMEN1NPSR1
SCHEMBL1745729 0.87 PPARD (0.49) FFAR1GSTO1KMT2AMEN1NPSR1
SCHEMBL3921201 0.86 FFAR1 (0.51) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1744650 0.86 PPARD (0.57) FFAR1FFAR4KMT2AMEN1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885GSTO1 3920/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.