SCHEMBL1746802

SCHEMBL1746802

CCN(Cc1ccc(COc2ccc(CCC(=O)O)cc2)cc1)c1nc(-c2ccccc2)cs1

nearest known ligand 0.55

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 12/20 0.55
FFAR4 Q5NUL3 4/20 0.52
KMT2A Q03164 4/20 0.50
MEN1 O00255 3/20 0.50
NPSR1 Q6W5P4 1/20 0.50
PPARD Q03181 3/20 0.49
MAPT P10636 1/20 0.48
HTT P42858 1/20 0.48
AKR1B1 P15121 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3914638 0.93 FFAR1 (0.58) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1745053 0.93 FFAR1 (0.53) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1745444 0.92 KMT2A (0.48) FFAR1KMT2AMEN1NPSR1PPARD
SCHEMBL3912223 0.91 PPARD (0.57) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL3921961 0.91 PPARD (0.54) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL3913893 0.90 ATP4A (0.52) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1745532 0.90 FFAR1 (0.55) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1746715 0.89 PPARD (0.53) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL3911382 0.89 PPARD (0.58) FFAR1FFAR4KMT2AMEN1NPSR1
SCHEMBL1744670 0.89 FFAR1 (0.57) FFAR1FFAR4KMT2AMEN1NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR FFAR1 33/4885FFAR4 44/4885KMT2A 4408/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.