SCHEMBL1746887

SCHEMBL1746887

CC(C)CCN(Cc1ccc(COc2ccc(CCC(=O)O)cc2)cc1)c1nc(C(C)C)cs1

nearest known ligand 0.46

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 8/20 0.46
FFAR1 O14842 12/20 0.46
PPARG P37231 2/20 0.46
FFAR4 Q5NUL3 3/20 0.45
PPARA Q07869 1/20 0.42
AKR1B1 P15121 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3909663 0.92 FFAR1 (0.54) PPARDFFAR1PPARGFFAR4PPARA
SCHEMBL1744558 0.91 ADRB2 (0.39) PPARDFFAR1PPARG
SCHEMBL3913755 0.87 FFAR1 (0.54) PPARDFFAR1PPARGFFAR4PPARA
SCHEMBL1744725 0.87 FFAR1 (0.55) PPARDFFAR1PPARGFFAR4PPARA
SCHEMBL3918687 0.84 PPARD (0.45) PPARDFFAR1PPARGFFAR4
SCHEMBL3917969 0.83 PPARD (0.53) PPARDFFAR1PPARGFFAR4PPARA
SCHEMBL3920611 0.82 FFAR1 (0.44) PPARDFFAR1FFAR4
SCHEMBL3912217 0.81 FFAR1 (0.52) PPARDFFAR1PPARGFFAR4PPARA
SCHEMBL3920779 0.80 PPARD (0.46) PPARDFFAR1FFAR4
SCHEMBL1744677 0.79 FFAR1 (0.47) PPARDFFAR1PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR PPARD 326/4885FFAR1 33/4885PPARG 225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.