Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 8/20 | 0.45 |
| ▸ | CDK8 | P49336 | 8/20 | 0.45 |
| ▸ | AXL | P30530 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.41 |
| ▸ | MET | P08581 | 2/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17469719 | 0.77 | KIT (0.59) | CCNCCDK8AXLLRRK2MET | |
| SCHEMBL17469641 | 0.73 | KIT (0.47) | MAPK1 | |
| SCHEMBL17469656 | 0.72 | KIT (0.43) | — | |
| SCHEMBL25419916 | 0.71 | LRRK2 (0.52) | CCNCCDK8LRRK2METAURKB | |
| SCHEMBL20916078 | 0.69 | MET (0.49) | CCNCCDK8LRRK2METAURKB | |
| SCHEMBL31165753 | 0.69 | MET (0.49) | CCNCCDK8LRRK2METAURKB | |
| SCHEMBL967870 | 0.69 | KCNH2 (0.54) | CCNCCDK8AXLLRRK2ACVR1 | |
| SCHEMBL19532040 | 0.66 | KIT (0.46) | — | |
| SCHEMBL30003784 | 0.66 | KIT (0.46) | — | |
| SCHEMBL25427609 | 0.65 | LRRK2 (0.49) | CCNCCDK8LRRK2AURKBGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016014674-A1 | LINKED DIARYL COMPOUNDS WITH ANTICANCER PROPERTIES AND METHODS OF USING THE SAME | UNIVERSITY OF MARYLAND, COLLEGE PARK (US) | 2016-01-28 | — | — | WO | disclosed |