SCHEMBL1747398

SCHEMBL1747398

CCCN(Cc1ccc(COc2ccc(CCC(=O)O)cc2)cc1)c1nc(C)c(C)s1

nearest known ligand 0.54

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 10/20 0.54
PPARG P37231 3/20 0.51
FFAR1 O14842 8/20 0.50
FFAR4 Q5NUL3 3/20 0.49
PPARA Q07869 2/20 0.49
LMNA P02545 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
AKR1B1 P15121 1/20 0.43
BCHE P06276 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1746697 0.90 PPARD (0.44) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL1744702 0.88 PPARD (0.54) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL1745053 0.82 FFAR1 (0.53) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL1996517 0.81 FFAR1 (0.54) PPARDPPARGFFAR1FFAR4AKR1B1
SCHEMBL1745514 0.80 PPARD (0.46) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL2000270 0.80 KMT2A (0.49) PPARDPPARGFFAR1FFAR4
SCHEMBL1745418 0.80 FFAR1 (0.64) FFAR1FFAR4LMNAL3MBTL1AKR1B1
SCHEMBL1633772 0.79 PPARD (0.49) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL3920051 0.79 PPARD (0.55) PPARDPPARGFFAR1FFAR4PPARA
SCHEMBL1745385 0.78 PPARD (0.55) PPARDPPARGFFAR1FFAR4PPARA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1559422-B1 RECEPTOR FUNCTION CONTROLLING AGENT TAKEDA PHARMACEUTICAL (JP) 2014-04-30 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
EP-2385032-A1 GPR40 Receptor function regulator Takeda Pharmaceutical Company Limited (JP) 2011-11-09 EP disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-7960369-B2 Receptor function regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2011-06-14 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
US-20090012093-A1 Receptor Function Regulator TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-01-08 US disclosed
EP-1559422-A1 RECEPTOR FUNCTION CONTROLLING AGENT Takeda Pharmaceutical Company Limited (JP) 2005-08-03 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090012093-A1 Receptor Function Regulator GPR119, GIPR, INSR PPARD 326/4885PPARG 225/4885FFAR1 33/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.